Fig. 2 | Scientific Reports

Fig. 2

From: VHL ameliorates arecoline-induced oral submucosal fibrosis by promoting HDAC6 ubiquitination and blocking NF-κB pathway

Fig. 2

Upregulation of VHL inhibits arecoline induced fibrosis. (A, B) The VHL plasmid was transfected into BMFs. The level of VHL was analyzed by RT-qPCR and WB. (C) The contraction activity of BMFs was determined by collagen gel contraction assay. (D) Effects of VHL overexpression on wound closure in arecoline -treated BMFs. Light microscopic images of BMFs were taken at 0 h and 24 h after the infliction of a scratch. Magnification: × 5. Scale bars: 100 μm. (E) Changes of fibrosis protein markers expression in arecoline-treated BMFs. *P<0.5, **P<0.01, ***P<0.001.

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