Fig. 1
From: PTPRO represses breast cancer lung metastasis by inhibiting the JAK2-YAP axis
PTPRO suppresses the metastatic potential of breast cancer. (A) Representative images of lung metastasis in vivo and statistical analysis of the number of metastatic foci in the indicated groups of mice (n = 21). (B) The metastatic foci in the lungs were examined using HE staining. (C) PTPRO expression inversely correlates with the metastasis-related gene signature according to a gene set enrichment analysis plot. (GSE19615; P = 0.002; NES, normalized enrichment score). (D–E) The migration and invasion abilities of BT474-overexpressing PTPRO cells and ZR75-1-knockdown PTPRO cells were measured by Transwell and scratch healing assays, respectively (left). Quantitative analyses of cell migration and invasion (right). The error bars indicate the SEM. **P < 0.01, ***P < 0.001, ****P < 0.0001 by Student’s t test (A) or one-way ANOVA with post hoc intergroup comparisons (D).
