Table 1 Relative metabolic activity of Midazolam in different voriconazole concentrations.

From: A preliminary exploration of liver microsomes and PBPK to uncover the impact of CYP3A4/5 and CYP2C19 on tacrolimus and voriconazole drug-drug interactions

3A4 Substrate (Midazolam)

Area Ratio

% of NC

 

IC50 (µM)

Sample 1

Sample 2

Sample 3

Mean

SD

Sample 1

Sample 2

Sample 3

Mean

SD

P

 

NC

6.65

6.58

6.56

6.60

0.0473

101

99.7

99.4

100

0.716

  

PC

0.750

0.863

0.795

0.803

0.0569

11.4

13.1

12.1

12.2

0.862

  

0.08 µmol

6.11

6.41

6.21

6.24

0.153

92.6

97.2

94.1

94.6

2.32

  

0.4 µmol

7.33

7.06

6.76

7.05

0.285

111

107

102

107

4.32

< 0.0001

379.5

2 µmol

7.82

7.73

7.71

7.75

0.0586

119

117

117

118

0.888

  

10 µmol

7.99

8.04

7.87

7.97

0.0874

121

122

119

121

1.32

  

50 µmol

5.49

5.44

5.24

5.39

0.132

83.2

82.5

79.4

81.7

2.01

  
  1. NC Negative control; PC Positive control.
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