Table 2 Relative metabolic activity of testosterone in different voriconazole concentrations.
3A4 Substrate (Testosterone) | Area Ratio | % of NC | IC50 (µM) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sample 1 | Sample 2 | Sample 3 | Mean | SD | Sample 1 | Sample 2 | Sample 3 | Mean | SD | P | ||
NC | 14.1 | 14.4 | 13.6 | 14.0 | 0.404 | 100 | 103 | 96.9 | 100 | 2.88 | ||
PC | 0.489 | 0.524 | 0.488 | 0.500 | 0.0205 | 3.48 | 3.73 | 3.48 | 3.57 | 0.146 | ||
0.08 µmol | 14.5 | 15.9 | 16.2 | 15.5 | 0.907 | 103 | 113 | 115 | 111 | 6.47 | ||
0.4 µmol | 14.6 | 15.5 | 13.7 | 14.6 | 0.900 | 104 | 110 | 97.6 | 104 | 6.41 | < 0.0001 | 38.2 |
2 µmol | 12.8 | 13.4 | 13.3 | 13.2 | 0.321 | 91.2 | 95.5 | 94.8 | 93.8 | 2.29 | ||
10 µmol | 11.7 | 10.9 | 10.9 | 11.2 | 0.462 | 83.4 | 77.7 | 77.7 | 79.6 | 3.29 | ||
50 µmol | 6.06 | 5.51 | 6.54 | 6.04 | 0.515 | 43.2 | 39.3 | 46.6 | 43.0 | 3.67 | ||
