Table 3 Inhibition of voriconazole on tacrolimus metabolism in human liver microsomes.

From: A preliminary exploration of liver microsomes and PBPK to uncover the impact of CYP3A4/5 and CYP2C19 on tacrolimus and voriconazole drug-drug interactions

Inhibition

Area Ratio

% of T0

Sample 1

Sample 2

Sample 3

Mean

SD

Sample 1

Sample 2

Sample 3

Mean

SD

P

0 min

           

NC-T0

0.155

0.131

0.138

0.141

0.01234

110

92.7

97.6

100

8.73

 

PC-T0(Ketoconazole)

0.120

0.121

0.127

0.123

0.00379

97.8

98.6

104

100

3.09

> 0.999

VRC 40µmol-T0

0.109

0.114

0.134

0.119

0.01323

91.6

95.8

113

100

11.1

 

30 min

           

NC-T30

0.00453

0.0119

0.00192

0.00612

0.00518

3.21

8.42

1.36

4.33

3.66

 

PC-T30(Ketoconazole)

0.0949

0.0954

0.0971

0.0958

0.00115

77.4

77.8

79.2

78.1

0.940

< 0.001

VRC 40µmol-T30

0.0147

0.0180

0.0144

0.0157

0.00200

12.4

15.1

12.1

13.2

1.68

 
  1. PC (Inhibitor: ketoconazole, 5µmol); NC negative control; PC Positive control; VRC Voriconazole.
Back to article page