Fig. 2

(a–c) Quantitative proteomics of tendon biopsies reflecting the inflammatory stage of healing. p-values from Mann-Whitney U test. *= ≥40% 0 values in good or poor outcome group. Abbreviations: ABI3BP=Abi family member 3 binding protein, AUC= Area under the ROC curve, ROC=Receiver Operating Characteristic, DEP = differentially expressed proteins, FC=Fold-change, IGHV4-39= Immunoglobulin heavy variable 4-39, IGKV2-40/IGKV2D-40= Immunoglobulin kappa variable 2-40/2D-40, PCYOX1= Prenylcysteine oxidase 1, STIP1= Stress-induced-phosphoprotein 1, YWHAQ= Tyroseine 3/Tryptophan 5 Monoxygenase activation protein theta. (a). Volcano plot of tendon biopsy proteins. DEPs in patients with DVT (n = 12) compared to patients without DVT (n = 27) at two weeks after surgery. The X coordinate represents Log2 (FC) and the Y coordinate represents −Log10 (p-value). Each dot represents a protein with red = up-regulated (n = 1; STIP1), blue = down-regulated (n = 5; ABI3BP, IGHV4-39*, IGKV2-40/IGKV2D-40*, PCYOX1*, and YWHAQ) and, black = non-differentially expressed proteins, (b). Dot-plots and ROC curves for DEPs in relation to DVT at two weeks after surgery. For STIP1, ROC when predicting DVT while for other proteins when predicting no DVT, (c). Dot-plots and ROC curves for DEPs in relation to DVT at one-year after surgery. For STIP1, ROC when predicting poor outcome (ATRS≤80) while for other proteins when predicting good outcome (ATRS>80).