Fig. 5
From: Treg derived Amphiregulin protects from murine lupus nephritis via tissue reparative effects
M/M-derived AREG does not alter renal outcome or fibrosis in LN. (a) Representative PAS-stained sections of kidneys from the indicated strains of mice at 12 months of pristane-induced-LN. (b) Quantification of abnormal glomeruli in kidneys of LysMcre x AREGfl/fl and control mice at 12 months of pristane-induced LN. (c) Representative Sirius Red-stained sections of kidneys from the indicated strains of mice at 12 months of pristane-induced LN. (d) Quantification of fibrosis in kidneys of LysMcre x AREGfl/fl and control mice at 12 months of pristane-induced LN. (e-f) Cytokine expression by Teffs in the (e) kidney and spleen (f) of LysMcre x AREGfl/fl mice or controls at 12 months of pristane-induced LN. (g) Kidney M/M polarization into pro- (M1) and anti-inflammatory (M2) phenotypes as measured by expression of Ly6C in the indicated strains of mice at 12 months after pristane injection. Symbols show individual animals and horizontal lines show mean values. Error bars show the standard error of the mean. *p < 0.05.
