Fig. 2

RNA sequencing revealed temporal changes in gene expression in synovium and cartilage after overloading. (a) PCA showing gene expression changes over time in synovium and cartilage samples. Arrows indicate the time course of tissue sampling; while dashed arrows represent the R24 group compared with the S24 group. (b) Number of differentially expressed genes (DEGs) between different time points in synovium and cartilage samples.