Fig. 8 | Scientific Reports

Fig. 8

From: Short-term overloading exercise attenuates articular chondrocyte features partly via synovium–cartilage interactions mediated by inhibin subunit beta A

Fig. 8

Identification of Inhba as an upstream synovial factor for transcriptomic changes in cartilage following repeated overloading. (a) Temporal changes in the expression of cytokine genes in the synovium with fold change > 2 at any time point. The analysis was performed on genes associated with the “cytokine activity” term in GO molecular functions. (b) Heatmaps of the top-30 upregulated cytokines based on comparisons between two time-points, ordered by fold-change values. Comparisons between the S1 vs. control groups (left), the R24 vs. control groups (middle), and the R24 vs. S24 groups (right). (c) Upstream cytokines or growth factor candidates predicted by ingenuity pathway analysis to regulate gene expression changes in cartilage in the R24 group.

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