Fig. 9

Upregulation of Inhba expression in the synovial lining layer and time course-dependent effects of activin A on primary cultured chondrocytes. (a) Immunofluorescence of Inhba in the control , S24, and R24 groups. Inset boxes in the left-hand panels indicate the locations of the enlarged images of the lining and sublining layers shown in the right-hand panels. The percentage of the Inhba-positive area in the lining region is shown. (b) Time course of mRNA levels of marker genes in the cartilage following recombinant human activin A treatment. P-values were determined by one-way ANOVA followed by Dunnett’s test. Data are expressed as dot plots and mean ± SD.