Fig. 2
(A–I). GABAergic systems influenced by optogenetic dopamine dependent medial forebrain bundle (mfb) stimulation and dopamine independent mfb Deep Brain Stimulation (DBS). (A) Representative picture of GABAA/GAD1 gene expression in the medial prefrontal cortex (mPFC), lateral habenula (LHb), dorsal striatum (DStr), and nucleus accumbens (NAC) influenced by mfb-DBS. (B) The immunoreactive positive (IR+) cells for GABAA in right (implanted) mPFC. (C) The IR + cells for GABAA in right (implanted) LHb. (D) The ipsilateral/contralateral ratio of IR + cells in mPFC. (E) The ipsilateral/contralateral ratio of IR + cells in LHb. (F) The IR + cells for GAD1 in right (implanted) DStr. (G) The IR + cells for GAD1 in right (implanted) NAC. (H) The ipsilateral/contralateral ratio of IR + cells in DStr. (I) The ipsilateral/contralateral ratio of IR + cells in NAC. Statistical significance is indicated as follows: *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.
