Fig. 3 | Scientific Reports

Fig. 3

From: Acute and chronic gene expression activation following medial forebrain bundle DBS and selective dopamine pathway stimulation

Fig. 3

(AG) GABAergic systems were not influenced by optogenetic dopamine dependent medial forebrain bundle (mfb) stimulation and dopamine independent mfb Deep Brain Stimulation (DBS). (A) Representative picture of GABAA/GAD1 expression in the ventral tegmental area (VTA), substantia nigra (SN), and hippocampus (HPC) influenced by mfb-DBS. (B) The immunoreactive positive (IR+) cells for GABAA in right (implanted) VTA. (C) the ipsilateral/contralateral ratio of IR + cells in VTA. (D) The IR + cells for GABAA in right (implanted) SN. (E) the ipsilateral/contralateral ratio of IR + cells in SN. (F) The IR + cells for GAD1 in right (implanted) HPC. (G) the ipsilateral/contralateral ratio of IR + cells in HPC. Statistical significance is indicated as follows: *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.

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