Fig. 5 | Scientific Reports

Fig. 5

From: Acute and chronic gene expression activation following medial forebrain bundle DBS and selective dopamine pathway stimulation

Fig. 5

(A–E) Reward and antireward center glutamatergic systems were not influenced by optogenetic dopamine dependent medial forebrain bundle (mfb) stimulation and dopamine independent mfb Deep Brain Stimulation (DBS). (A) Representative picture of Vglu2 expression in the lateral habenula (LHb) and ventral tegmental area (VTA). (B) The immunoreactive positive (IR+) cells for Vglu2 in right (implanted) LHb. (C) The IR + cells for Vglu2 in right (implanted) VTA. (D) The ipsilateral/contralateral ratio of IR + cells in LHb. (E) the ipsilateral/contralateral ratio of IR + cells in VTA. Statistical significance is indicated as follows: *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.

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