Fig. 7
Increased glucose-mediated metabolic activity is detected in the heart and skeletal muscle. Glucose metabolic activity is increased in the heart of Slc6a8-/y mice (A, representative images in B1, B2, B3 [heart = circle]) compared to WT mice (representative images in C1, C2, C3). Similarly, glucose metabolic activity is increased in the skeletal muscle of Slc6a8-/y mice (D, representative images in E1, E2, E3) compared to wild type mice (representative images in F1, F2, F3). Blood glucose is reduced in Slc6a8-/y mice compared to wild type whether in the fed state (G) or fasted (H) Similarly, plasma insulin level is also decreased in Slc6a8-/y mice (I). Data is presented as mean + standard deviation. P values of ≤ 0.05 are shown with one (*) asterisk, ≤ 0.01 are shown with two (**), and P values less than 0.0001 are shown with four (****).
