Fig. 9 | Scientific Reports

Fig. 9

From: [18F]FDG-PET and [18F]MPPF-PET are brain biomarkers for the creatine transporter Slc6a8 loss of function mutation

Fig. 9

A model of the effect of loss of function of the creatine transporter on glucose uptake. The normal creatine/phosphocreatine shuttle is represented in (A) while (B) is a model of what occurs when the creatine transporter is mutated and the brain relies on glucose solely as the source of energy. (ATP, adenosine triphosphate; ADP, adenosine diphosphate; CRT, creatine transporter; Cr, creatine; PCr, phosphocreatine; CK, creatine kinase.

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