Table 1 Baseline demographics and disease characteristic.

From: Alterations in nailfold videocapillaroscopy among patients with connective tissue diseases combined with pulmonary arterial hypertension: A cross-sectional study

Variables

CTD-PAH (n = 58)

CTD-non-PAH (n = 293)

Non-CTD healthy people

(n = 30)

P1 value*

P2 value**

Age, years

51.1 ± 15.2

46.4 ± 15.7

47.1 ± 6.9

0.035

0.091

Female, n(%)

52(89.7%)

241(82.3%)

23(76.7%)

0.165

0.249

Disease duration, months

80(140)

63(142)

 

0.427

 

Duration from PAH diagnosis, months

5(38)

—

   

Raynaud’s phenomenon, n (%)

31(53.4%)

95(32.4%)

 

0.002

 

Diseases

Rheumatoid arthritis, n (%)

7(12.1%)

57(19.5%)

 

0.096

 

Systemic Lupus Erythematosus, n (%)

18(31.0%)

88(30.0%)

  

Dermatomyositis, n (%)

5(8.6%)

54(18.4%)

  

Sjögren’s syndrome, n (%)

14(24.1%)

47(16.0%)

  

Systemic sclerosis, n (%)

14(24.1%)

47(16.0%)

  

WBC, *109 /L

5.40 ± 2.46

6.14 ± 3.21

 

0.098

 

HB, g/L

111.6 ± 17.5

116.3 ± 19.0

 

0.069

 

PLT, *109/L

167.0 ± 77.0

215.2 ± 88.9

 

0.001

 

ALT, U/L

24.30 ± 24.29

36.72 ± 72.55

 

0.021

 

AST, U/L

36.61 ± 95.07

36.67 ± 84.51

 

0.996

 

ALB, g/L

36.61 ± 6.67

36.42 ± 5.26

 

0.811

 

Cr, μmol/L

58.8 ± 28.3

57.2 ± 38.8

 

0.713

 

TSH, mIU/L

3.48 ± 4.23

2.59 ± 2.46

 

0.038

 

T3, nmol/L

3.60 ± 0.99

3.82 ± 1.12

 

0.184

 

T4, nmol/L

15.19 ± 2.96

15.66 ± 2.62

 

0.242

 

Pro, n (%)

17(30.9%)

92(32.1%)

 

0.867

 

BLD, n (%)

16(29.6%)

67(23.3%)

 

0.323

 

Auto-antibody

ANA, n (%)

39(67.2%)

192(65.5%)

 

0.802

 

Anti-dsDNA, n (%)

11(19.0%)

52(17.7%)

 

0.825

 

Anti-SSA, n (%)

26(44.8%)

101(34.5%)

 

0.134

 

Anti-SSB, n (%)

10(17.2%)

29(9.9%)

 

0.104

 

Anti-Ro52, n (%)

27(46.6%)

117(39.9%)

 

0.349

 

Anti-RNP, n (%)

18(31.0%)

65(22.2%)

 

0.147

 

Anti-Scl70, n (%)

5(8.6%)

32(10.9%)

 

0.602

 

Anti-SM, n (%)

11(19.0%)

31(10.6%)

 

0.072

 

AHA, n (%)

11(19.0%)

46(15.7%)

 

0.538

 

IgG, g/L

15.29 ± 6.68

13.80 ± 5.45

 

0.072

 

IgM, g/L

1.42 ± 1.30

1.41 ± 1.92

 

0.971

 

IgA, g/L

2.50 ± 1.23

2.58 ± 1.34

 

0.653

 

C4, g/L

0.18 ± 0.12

0.198 ± 0.93

 

0.204

 

C3, g/L

0.87 ± 0.31

1.02 ± 0.33

 

0.002

 

ESR, mm/h

33.8 ± 28.5

33.1 ± 27.1

 

0.872

 

CRP, mg/L

12.13 ± 30.33

11.39 ± 20.55

 

0.819

 

D-Dimer, mg/L

1.62 ± 3.12

0.92 ± 1.55

 

0.113

 
  1. Categorical variables are expressed as frequencies and percentages, n (%). Continuous variables are presented as mean ± standard deviation or median value with interquartile range. P < 0.05 considered statistically different. CTD-PAH pulmonary arterial hypertension associated with connective tissue disease, CTD-non-PAH connective tissue disease not complicated with pulmonary arterial hypertension, WBC white blood cell, HB hemoglobin, PLT platelet, ALT alanine transaminase, AST aspartate aminotransferase, ALB albumin, Cr creatinine, TSH thyroid-stimulating hormone, T3 triiodothyronine, T4 thyroxin, Pro urine protein, BLD urine occult blood, ANA antinuclear autoantibodies, AHA antihistone antibodies, C3 Complement 3, C4 Complement 4, ESR erythrocyte sedimentation rate, CRP C-reaction protein.
  2. * P1 value refers to differences between CTD-PAH and CTD-non-PAH. ** P2 value refers to differences among CTD-PAH, CTD-non-PAH and non-CTD healthy people.
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