Table 1 List of engineered TCR-T cell models and their cellular properties.
Cellular properties TCR-T models | MC2 targeting TCR expression | Constitutive PD-L1 expression | PDCD1 gene knockout (PD1−) | |
|---|---|---|---|---|
1 | MC2-TCR-T | + | − | No |
2 | MC2-TCR-TPD1− | + | − | Yes |
3 | PDL1-MC2-TCR-T | + | + | No |
4 | PDL1-MC2-TCR-TPD1− | + | + | Yes |
5 | MC2-TCR-J | + | − | No |
6 | PDL1-MC2-TCR-J | + | + | No |
