Fig. 4
AAV-IKV Mediated Delivery of Decorin Inhibits AAV-IKV-TGFβ2CS induced IOP. (A) AAV-IKV-Decorin or AAV-IKV-pA injected intracamerally into six week old C57BL/6J mice and stained for decorin after 7 days post injection. Whereas there is a detectable level of decorin in AAV-IKV-pA injected eyes in the ciliary body, there is a significantly higher level of decorin expression in the AAV-IKV-Decorin injected eyes. (B) We found that while there was no statistically significant difference in IOP between the AAV-IKV-TGFβ2CS and AAV-IKV-TGFβ2CS + AAV-IKV-Decorin groups initially, i.e. at day 8 (p = 0.13) and day 16 (p = 0.7), there was a sustained lowering in IOP in AAV-IKV-TGFβ2CS + AAV-IKV-Decorin injected group relative to the AAV-IKV-TGFβ2CS injected group at all subsequent time points examined (p < 0.0001, D23; p < 0.0001, D30; p = 0.016, D37; p = 0.005, D44).
