Fig. 5

Treatment of surgical site infection (SSI) with alginate/collagen clindamycin hydrogel (A) Bioluminescence signals in mice following treatment with either saline control group (n = 5), systemic antibiotic (n = 5), antibiotic hydrogel (n = 5), or low dose antibiotic (n = 5). (B). Total mean bioluminescence changes between saline control group, systemic antibiotic, local hydrogel injection, and low dose antibiotic (20 mg/kg). Mice that received a low dose of systemic antibiotic (20 mg/kg) equivalent to hydrogel injection continued to have infection until the end of treatment. *p < 0.05, †p < 0.01. Systemic antibiotic, systemic antibiotic (low dose), or targeted hydrogel versus saline group (one-way ANOVA with Tukey tests). Error bars represent ± SD (n = 5).