Table 4 Comparisons of the prognostic performance of the two-stage scoring system with GRACE, TIMI risk score, TIMI risk index and C-ACS for 30-day mortality.

From: Development and validation of a risk score for predicting 30-day mortality in patients with ST elevation myocardial infarction

Classifier

AUC difference (95% CI)

P value

NRI (95% CI)

P value

IDI (95% CI)

P value

For the FMC stage risk score (in derivation dataset)

Versus TIMI risk score

-0.001(-0.020,0.018)

0.944

0.133(0.003,0.263)

0.045

0.006(-0.010,0.022)

0.466

Versus TIMI risk index

0.014(-0.007,0.034)

0.199

0.232(0.103,0.362)

< 0.001

-0.009(-0.031,0.013)

0.433

Versus GRACE score

0.005(-0.013,0.022)

0.608

0.115(-0.015,0.245)

0.082

0.006(-0.012,0.025)

0.498

Versus C-ACS

0.045(0.020,0.069)

< 0.001

0.402(0.275,0.530)

< 0.001

0.031(0.015,0.047)

< 0.001

For the in-hospital stage risk score (in derivation dataset)

Versus TIMI risk score

0.037(0.017,0.057)

< 0.001

0.072(0.0488,0.095)

< 0.001

0.516(0.391,0.641)

< 0.001

Versus TIMI risk index

0.051(0.028,0.075)

< 0.001

0.057 (0.031,0.084)

< 0.001

0.555(0.427,0.682)

< 0.001

Versus GRACE score

0.042(0.022,0.063)

< 0.001

0.072 (0.052,0.093)

< 0.001

0.547 (0.422,0.672)

< 0.001

Versus C-ACS

0.083(0.058,0.107)

< 0.001

0.097(0.074,0.120)

< 0.001

0.656(0.536,0.775)

< 0.001

For the FMC stage risk score (in internal validation dataset)

Versus TIMI risk score

0.010(-0.018,0.038)

0.491

0.149(-0.054,0.351)

0.151

0.005(-0.024,0.035)

0.726

Versus TIMI risk index

0.035(0.003,0.067)

0.033

0.465(0.264,0.667)

< 0.001

0.028(-0.008,0.065)

0.131

Versus GRACE score

-0.001(-0.026,0.024)

0.940

0.039(-0.164,0.242)

0.707

-0.011(-0.046,0.024)

0.545

Versus C-ACS

0.031(-0.004,0.067)

0.081

0.325(0.123,0.526)

0.002

0.015(-0.017,0.047)

0.364

For the in-hospital stage risk score (in internal validation dataset)

Versus TIMI risk score

0.043(0.013,0.073)

0.005

0.076(0.040,0.111)

< 0.001

0.579(0.385,0.773)

< 0.001

Versus TIMI risk index

0.068(0.034,0.102)

< 0.001

0.099(0.059,0.138)

< 0.001

0.703(0.506,0.899)

< 0.001

Versus GRACE score

0.032(0.006,0.058)

0.016

0.060(0.026,0.093)

< 0.001

0.593(0.404,0.782)

< 0.001

Versus C-ACS

0.064(0.029,0.100)

< 0.001

0.085 (0.049,0.122)

< 0.001

0.682(0.496,0.868)

< 0.001

  1. AUC, area under the curve; CI, confident interval; NRI, net reclassification improvement; IDI, integrated discrimination improvement; TIMI, thrombolysis in myocardial infarction. GRACE, global registry of acute coronary events. C-ACS, Canada acute coronary syndrome risk score
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