Fig. 5 | Scientific Reports

Fig. 5

From: Increased individual variability in functional connectivity of the default mode network and its genetic correlates in major depressive disorder

Fig. 5

Gene expression profiles related to MDD-related IVFC alterations. (A) Regional mapping of PLS1 scores and Z-values (both sides). The z-values were obtained from between-group comparisons of IVFC for MDD and HC. Explained variance of each PLS component and the correlation between PLS1 scores and Z-map (middle). (B) Left: Bubble plot of top 20 enrichment analysis results. This bubble plot illustrates the functional annotations for PLS1 + genes based on Gene Ontology (GO) terms and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. The size of each bubble reflects the number of genes that are shared between the given term and the other terms shown, while the color bar represents the Benjamini–Hochberg False Discovery Rate (BH-FDR) corrected p-value. Right: Network of enriched terms. This network derived from Metascape, features nodes representing individual pathways, color-coded by cluster to indicate potential functional relationships, on the left side of this network enriched terms, dots were used to represent the color of each cluster, and these are matched with the terms in the left bubble plot.

Back to article page