Fig. 3
Gene ontology term enrichment analysis of CTRL and SR1 groups. (A–F) are structured as follows: Gene Ontology-Biological Process (GO-BP) is shown in the first column (left), Gene Ontology-Cellular Component (GO-CC) in the second column (middle), and Gene Ontology-Molecular Function (GO-MF) in the third column (right). Horizontally, the figures compare AML versus HD in the first and second rows, FA versus HD in the third and fourth rows, and AML versus FA in the fifth and sixth rows. Panels (A), (C), and (E) depict comparisons under CTRL conditions, while panels (B), (D), and (F) show comparisons under SR1 treatment. (A–F), lollipop plots illustrate pathways sorted by gene count on the x-axis, with point sizes representing − log10(FDR) values and colors indicating fold enrichment. The x-axis represents the number of genes per pathway, with a color gradient ranging from red (high fold enrichment) to blue (low fold enrichment). Larger dots indicate pathways with lower − log10(FDR) values, highlighting their statistical significance. This visualization assists in identifying significantly enriched GO terms, with the color gradient providing a clear distinction between high and low fold enrichment levels. For example, pathways with larger dots and red hues are highly significant, while those with blue and smaller dots show lower significance. All graphs were generated using ShinyGO v8.0 (http://bioinformatics.sdstate.edu/go/) webtool.
