Fig. 5
From: Establishment and genomic profiling of cholangiocarcinoma cells with functional characterization
Relative cytotoxicity of chemotherapeutic drugs in CCA cell lines. (A–F) Sensitivity of CCA cells to cisplatin (Cis) and gemcitabine (Gem). The cells were treated with Gem or Cis for 24, 48, or 72 h. Cell cytotoxicity was assessed via the MTT assay. Dose‒response curves are expressed as the mean ± SD of three independent experiments. (G) The IC50 values of single drug treatment at 24, 48, and 72 h are shown. (H–J) The cytotoxicities of Gem, Cis, and the combination of Gem and Cis at concentrations up to their IC50 values at 72 h were determined via the MTT assay. (K‒M) Drug synergism analysis was performed via a two-agent model in which the Bliss score was compared.
