Fig. 2 | Scientific Reports

Fig. 2

From: Favorable pharmacokinetic and tolerability profiles make carprofen an attractive analgesic for subcutaneous injection and oral self-administration in rats

Fig. 2

Long plasma elimination half-life following single s.c. injection of 5 mg/kg CAR and stable CAR plasma levels during oral self-administration of 10 mg/kg/24 h. (a) Plasma concentration-time curve after s.c. injection is presented. Individual data points (n = 6, 3 male and 3 female rats per time point) and mean of all animals per time point (black line) are presented. Estimated minimal therapeutic plasma level (dotted line) is displayed according to reference (13)). (b) Plasma concentration-time curve during oral intake of CAR (intended dose: 10 mg/kg/24 h) via d.w. over 5 consecutive days. Individual data points (n = 6, 3 male and 3 female rats per time point) and mean of all animals per time point (black line) are presented. Estimated minimal therapeutic plasma level (dotted line) is displayed according to reference (13). (c) CAR dose intake from d.w. (mg/kg) per individual rat is displayed for 24 h intervals after treatment start and remains in the area of the target dose intake of 10 mg/kg/24 h (dotted line). Dose intake was calculated from fluid consumption/24 h and concentration of CAR-medicated d.w. (n = 7 cages per sex, 3 rats per cage).

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