Fig. 4
From: Novel composite bone cement modulates inflammatory response in vitro
Changes in fluorescence intensity of ES-PMMA bone cement affecting inflammatory factors in a co-culture system. By immunofluorescence we found that in the co-culture system of the two cells, the fluorescence intensity of the inflammatory proteins IL-6, TNF-α and ICAM was increased in the LPS-induced group compared to the blank control group (***P < 0.001), and the fluorescence intensity of IL-10 was reduced (***P < 0.001); in contrast, the fluorescence intensity of the IL-6, TNF-α, and ICAM was reduced in the ES-PMMA + LPS group compared to the LPS-induced group (***P < 0.001); and the fluorescence intensity of the IL-10 was increased (***P < 0.001). This indicates that ES-PMMA bone cement in the co-culture system has anti-inflammatory potency. This indicates that ES-PMMA bone cement in the co-culture system has anti-inflammatory potency. (n = 3).
