Table 3 Mendelian randomization analysis results of the causal relationship between circulating metabolites and Behçet’s disease.
Exposure | Outcome | Nsnp | Method | MR | Heterogeneity | Horizontal pleiotropy | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
OR (95%CI) | P value | I2 (%) | Cochran’s Q | P-value | Egger intercept | SE | P-value | MR-PRESSO global test p | ||||
Concentration of very large HDL particles | Behcet’s disease | 30 | MR Egger | 0.918 (0.1938–4.3491) | 0.9149 | 0 | 26.7061 | 0.5343 | 0.0934 | 0.0830 | 0.2696 | 0.5190 |
Weighted median | 1.853 (0.6234–5.5078) | 0.2671 | – | – | – | – | – | – | 0.5190 | |||
Inverse variance weighted | 2.0499 (1.0364–4.0545) | 0.0391 | 0 | 27.9745 | 0.5193 | – | – | – | 0.5190 | |||
Simple mode | 2.2696 (0.4014–12.8322) | 0.3614 | – | – | – | – | – | – | 0.5190 | |||
Weighted mode | 1.8064 (0.6351–5.1379) | 0.2767 | – | – | – | – | – | – | 0.5190 | |||
