Fig. 3 | Scientific Reports

Fig. 3

From: In-silico analysis unveiling the role of cancer stem cells in immunotherapy resistance of immune checkpoint-high pancreatic adenocarcinoma

Fig. 3

Extrinsic immunotherapy-resistance contributing immune and CAF infiltration scores for PAAD and LUAD. TIMER2.0 database procured CIBERSORT scores for immune cell infiltration represented in the form of bar graph for TCGA tumors, PAAD (n = 179) and LUAD (n = 208) for (A) CD8+ T cell, (B) Activated CD4 + memory T cell, (C) T-regulatory cell, (D) Activated NK cell, (E) M1 macrophage, (F) M2 macrophage and (G) activated myeloid dendritic cell. (H) Bar graph representing EPIC score for CAF infiltration in PAAD (n = 179) and LUAD (n = 208). Data were represented as the mean ± SEM and student’s t-test (unpaired) was used to assess the data where *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001. CAF: Cancer-associated fibroblast, PAAD: Pancreatic adenocarcinoma, LUAD: Lung adenocarcinoma.

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