Fig. 4 | Scientific Reports

Fig. 4

From: In-silico analysis unveiling the role of cancer stem cells in immunotherapy resistance of immune checkpoint-high pancreatic adenocarcinoma

Fig. 4

Intrinsic immunotherapy-resistance contributing factors in PAAD and LUAD. cBioportal database demonstrating (A) tumor mutational burden (TMB) depicted by total patients showing number of mutations/Mb, and (B) mutational count depicted by number of patients presenting total mutations for PAAD (n = 184) (left panel) and LUAD (n = 566) (right panel). Bar plots demonstrating percentage mutational status for (C) mismatch repair genes and, (D) key genes, TP53, KRAS, CDKN2A and SMAD4 for PAAD (n = 184) and LUAD (n = 566). (E) Kaplan Meier overall survival (OS) plot for PAAD patients (n = 184) considering altered or unaltered cohorts for TP53, KRAS, CDKN2A and SMAD4 genes. PAAD: Pancreatic adenocarcinoma, LUAD: Lung adenocarcinoma.

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