Fig. 7 | Scientific Reports

Fig. 7

From: In-silico analysis unveiling the role of cancer stem cells in immunotherapy resistance of immune checkpoint-high pancreatic adenocarcinoma

Fig. 7

Correlation of pancreatic CSC genes with immunotherapy-resistance pathway genes. (A) UMAP/tSNE plot of PAAD tumor dataset (Olive−204-tpm-gse93326; tSNE perplexity 23) from ‘R2: Genomics Analysis and Visualization Platform’ demonstrating samples (marked) with high expression of CSC markers, ABCB1, ABCG2, ALDH1A1, CD44, CD133 (PROM1), CSCR4, MET, and OCT4 (POU5F1). (B) The same group marked in (A) depicting high expression of immunotherapy-resistance associated signaling genes, WNT1, CTNNB1, PIK3CA, AKT1, MTOR, MAPK1, MAP2K1, RAF1, EGFR. (C) Correlation among the CSC genes from (A) and signaling genes taken in (B) were analyzed from TIMER database in PAAD (n = 179) and represented as heatmap depending on values from Spearman correlation. PAAD: Pancreatic adenocarcinoma, CSC: Cancer stem cell.

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