Table 2 Pharmacokinetic data in serum for all analytes and individuals.
(9R)–HHC | (9S)–HHC | 11–OH–HHC | (9R)–HHC–COOH | ||
|---|---|---|---|---|---|
O1 | cmax, ng/mL | 12.0 | 4.39 | 9.49 | 37.1 |
tmax, h | 2 | 2 | 2.5 | 2.5 | |
ke | 0.41 | 0.49 | 0.35 | 0.0072 | |
t1/2, h | 1.70 | 1.42 | 1.97 | 96.1 | |
O2 | cmax, ng/mL | 7.07 | 2.47 | 5.84 | 10.7 |
tmax, h | 1.25 | 1.25 | 2.25 | 8 | |
ke | – | – | – | – | |
t1/2, h | – | – | – | – | |
O3 | cmax, ng/mL | 2.75 | 1.07 | 3.66 | 13.4 |
tmax, h | 1.75 | 1.75 | 3 | 2.75 | |
ke | 0.25 | 0.36 | 0.24 | 0.011 | |
t1/2, h | 2.78 | 1.94 | 2.87 | 61.8 | |
I1 | cmax, ng/mL | 15.8 | 5.93 | 0.93 | 1.66 |
tmax, h | 0.05 | 0.05 | 0.58 | 0.25 | |
ke | 0.46 | 0.59 | 0.27 | 0.010 | |
t1/2, h | 1.52 | 1.18 | 2.58 | 66.2 | |
I2 | cmax, ng/mL | 179 | 61.3 | 3.88 | 13.6 |
tmax, h | 0.10 | 0.05 | 1 | 0.45 | |
ke | 0.35 | 0.36 | 0.27 | 0.0086 | |
t1/2, h | 1.97 | 1.95 | 2.56 | 81.0 | |
I3 | cmax, ng/mL | 142 | 48.2 | 4.76 | 10.5 |
tmax, h | 0.033 | 0.033 | 0.10 | 0.15 | |
ke | 0.33 | 0.37 | 0.26 | 0.020 | |
t1/2, h | 2.11 | 1.87 | 2.64 | 35.4 | |