Fig. 2
Development of status epilepticus (SE), handling-induced seizures and spontaneously recurring seizures following acute soman exposure. Following acute soman exposure, non-perfused (NP) and perfused (P) rats were observed for initial SE and seizure development. The severity of status epilepticus (SE) in soman-exposed rats from both the NP and P groups is shown as a mixed-sex cohort (a). All rats in the NP and P groups (10 per group) were monitored for handling-induced seizures over 14 days (days 2–15 post-soman) (b). In panel (b), the number of male rats with and without seizures is indicated by solid black and black stripes, respectively. In contrast, the number of female rats with and without seizures is indicated by a solid red or red stripe, respectively. Continuous vEEG monitoring of P group soman rats to track SRS. The percentage of male and female rats with SRS on a particular day is shown on a 60-day timeline (c). In panel (c), the days when all 10 rats (5 males and 5 females) experienced SRS are highlighted within a box. Normality was assessed with the Shapiro–Wilk Test, n = 10 (5/sex); no significance vs control by Unpaired t-test.
