Fig. 5

Correlational profile of pro-inflammatory cytokine/chemokine in the brain, CSF, and serum. Correlation matrices of TNF-α, IL-6, IL-17A, MCP-1, IL-18, and IL-1α for CSF (a–f) between brain genes expression, secreted proteins in CSF and serum (a–f). Normality was assessed with the Shapiro–Wilk test. Values represent the correlation coefficient (center of each matrix square), n = 8 (4/sex). p < 0.05 versus control by Spearman correlation analysis (color represents strength and direction of correlation). No sex differences were observed, and data was pooled together.