Fig. 8 | Scientific Reports

Fig. 8

From: In vivo deletion of a GWAS-identified Myb distal enhancer acts on Myb expression, globin switching, and clinical erythroid parameters in β-thalassemia

Fig. 8

Phenotypic impact of Myb− 81kb enhKO in Hbbth1/th1 thalassemic mice. (a) experimental set-up, (b) spleen weight of control, Hbbth1/th1, and Hbbth1/th1::Myb− 81kb enhKO mice showing decreased splenomegaly. (c) Circulating erythroid blood parameters of 7–10 weeks old adult animals from the different genotypes. All data are expressed as the mean ± s.e.m. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.

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