Fig. 6
From: Engineering mouse chymotrypsin B1 for improved trypsinogen degradation
Potential enzyme–substrate interactions between the G236R mouse CTRB1 mutant and mouse anionic (T8) trypsinogen. Magnified view of the interaction between the Phe150 cleavage site region of anionic (T8) trypsinogen (gray) and the substrate binding pocket of mouse CTRB1 (yellow) rendered in cartoon representation. Presumed hydrogen bonds formed by the guanidino group of Arg236 with the indicated side-chain and main chain atoms of anionic (T8) trypsinogen are represented by dashed lines. The “active site” label refers to the catalytic triad of chymotrypsin.
