Fig. 3 | Scientific Reports

Fig. 3

From: Immunological and structural evaluation of the intranasally administrated CVB1 whole-virus and VLP vaccines

Fig. 3

Pilot animal study. (A) Immunization schedule. (B) Vaccine antigen-specific IgG, (C) IgG1 and (D) IgG2a antibody end point titers at week 6 after two subcutaneous immunizations with 2 µg vaccine antigen determined with indirect ELISA. Titers below 200 were assigned as negative result. (E) CVB1 neutralizing antibodies determined with microneutralization assay. Titers below 8 were assigned as a negative result. A-E). Data is shown as geometric mean with geometric SD. (F) Average weights of animals in each experimental group. Dashed line indicates the time point for booster vaccination. * = p < 0.05.

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