Fig. 1

Population wide relationship between polygenic score (PS) and spirometry results. Boxplots of median and interquartile range (IQR) FEV1 (A) or FEV1/FVC (B) z-score by PS group (defined by PS z-score above or below 1), whiskers extend to 1.5 times the IQR, datapoints outside this range are shown as points. P-value reported here was calculated using a two-sided t-test. While a statistically significant difference was observed in both measures, the magnitude of the difference in FEV1 z-score was small and unlikely to be clinically meaningful. Please refer to the text for P-values from the regression model adjusting for sex, age, and self-reported race as confounders.