Table 1 Summary of COVID-19 hallmarks and the genes associated with them.

From: Plasma metabolomic signatures for copy number variants and COVID-19 risk loci in Northern Finland populations

COVID-19 Hallmark

Genes

Haematological

ABO, BCL11A, FUT2, GATA2, ICAM4, LZTFL1, PLSCR1, SLC22A5, THBS3, TCF7L2

Divalent cations Fe2+/Mg2+/Ca2+

ANXA11, CIB4, CYP4B1, FDX2, MBL1P, NUCB1, PIR, SLC39A8

GTpase/GEF/GAP family, Protein translation

ARHGAP27, ARHGEF38, ARL17A, CEP97, EIF5AL1, LZTFL1, PLEKHM1, RAB2A, RASIP1

Voltage-gated ion transport, Mitochondria, ROS, Neurological

ACSF3, ATP11A, ATP5PO, ATP6V1G2, CAT, FOXG1, HCN3, KCNC3, MRPS6, MTX1, NSF, RPL24, SLC22A31, SLC34A2, SLC6A20, TOMM7, TRIMM46, TTC10

Macrophage biology

CCR1, CCR2, CCR3, CCR5, CSF3, ICAM3, IRF1, IRF7, NR1H2

  1. Genes listed above have been reported to have significant association with COVID-19 either from the GWAS of COVID-19 host genetics initiative study or the study involving GWAS of COVID-19 severity groups (including GSMR analysis) (Supplementary Table 6).
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