Fig. 5
Integration of Machine Learning Algorithm (Lasso Regression) and Protein–Protein Interaction (PPI) Analysis. (A) Venn diagram illustrating the intersection between differentially expressed upregulated genes (DEupSGs) and the core genes of the purple module. (B) Coefficient plot of Lasso regression across various penalty parameter values. (C) Cross-validation process of Lasso regression, highlighting the point with the minimum error, which corresponds to a core gene count of five. (D) Protein–protein interaction network constructed from the top five hub genes identified through the analysis. (E) Venn diagram representing the overlap between Lasso regression core genes and the top five hub genes from the PPI network.
