Fig. 5 | Scientific Reports

Fig. 5

From: Efficacy of xenogeneic fresh and lyophilized amniotic membranes on the healing of experimentally induced full-thickness skin wounds in dogs

Fig. 5

H&E staining of skin wounds from the different groups. A–C The wound region one week after wound induction. A Control group showing an opened wound area (forked arrow). B The fresh AM group showing granulation tissue with an influx of inflammatory cells (boxed inset). C Lyophilized AM group with pronounced granulation tissue (G) and angiogenesis (wavy arrows). D-F The wound area in the different groups 3 weeks after wound induction. A Control groups showing scabs (Sc) and blood vessels in the wound area (wavy arrows). B Fresh AM showing many blood vessels in the wound area (wavy arrows and inset box). Re-epithelization could be detected in fresh AM (Ep). C The lyophilized AM group showed re-epithelization of the epithelium (Ep) and a few new blood vessels (wavy arrow). G-I The wound area in the different groups 5 weeks after wound induction. The skin was relatively normal in all groups, consisting of epidermis (E) and dermis with remodeled connective tissue (CT). However, skin appendages were absent in the control group, and they were more abundant in the fresh AM and lyophilized AM groups. Abbreviations: E: epidermis; D: dermis; Hy: hypodermis; HG: hemorrhage; Sb: sebaceous gland; H: hair follicle; Sg: sweat gland.

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