Table 1 Clinical characteristics of patients with I-DiPO and S-DiPO.

From: Diffuse pulmonary ossification and its association with cicatricial organising pneumonia in idiopathic and secondary forms

 

Idiopathic (N = 18)

Secondary (N = 7)

Test result P value

Sex (M:F)

14:4

6:1

NS

 Male (M)

14 (77.8%)

6 (85.71%)

 Female (F)

4 (22.2%)

1 (14.29%)

Mean age at diagnosis of DiPO

37.8 (years)

67.8 (years)

< 0.05

Smoking status (N:F)

16:2

5:2

NS

 Never (N)

16 (88.9%)

5 (71.4%)

 Former (F)

2 (11.1%)

2 (28.6%)

Laboratory data

 ALP (U/L: 80–260)

218.31 (N = 16)

259.00 (N = 6)

NS

 Corrected Ca (mg/dL: 8.4–10.4)

9.43 (N = 16)

9.32 (N = 5)

NS

 P (mg/dL: 2.5–4.5)

3.20 (N = 13)

3.60 (N = 1)

NS

Lung function test

 %FVC

86.83 (N = 18)

90.45 (N = 4)

NS

 %FEV1

80.95 (N = 18)

87.75 (N = 4)

NS

Family history

2 (10%)

0

 

Deterioration of pulmonary ossification on HRCT

(N = 18)

(N = 4)

NS

 Stable

2 (11.1%)

1 (14.29%)

 Progression

13 (72.2%)

1 (14.29%)

 Unknown

3 (16.7%)

5 (71.4%)

Survival

(N = 18)

(N = 4)

< 0.05

 Alive

16 (88.9%)

3 (42.9%)

 Dead

0

3 (42.9%)

 Unknown

2 (11.1%)

1 (14.2%)

Underlying diseases

 

(N = 4)

 

 Interstitial pneumonia

 

5 (71.43%)

 

 Atrial fibrillation

 

3 (42.86%)

 

 Acute respiratory distress syndrome

 

1 (14.30%)

 

 Mitral stenosis

 

1 (14.30%)

 
  1. I-DiPO, idiopathic diffuse pulmonary ossification; S-DiPO, secondary diffuse pulmonary ossification; NS, not significant; ALP, alkaline phosphatas; Ca, corrected calcium; P, inorganic phosphorus; FVC, forced vital capacity; FEV1, forced expiratory volume in one second.
  2. Values represent the number of cases. Numbers in parentheses ( ) represent the percentages of patients in each group. Student’s t-test or Mann–Whitney U test was used to analyse age, while Fisher’s exact test was used to analyse sex and smoking status.