Table 3 Comparison of the pathological characteristics between I-DiPO and S-DiPO by type and grading.

From: Diffuse pulmonary ossification and its association with cicatricial organising pneumonia in idiopathic and secondary forms

Pathological type

Underlying diseases

No. of nodular type

No. of mixed type

No. of dendriform type

No. of dendriform type/all types

%

F test

P value

 
 

Idiopathic

0

5

13

13/18

72.2

  

Secondary-All

2

2

3

3/7

42.8

NS

 

Secondary-Af

2

1

0

0/3

0

< 0.05

 

Characteristic

Underlying diseases

No. of G0

No. of G1

No. of G2

No. of G3

No. of G2 + 3/all grades

%

F test

P value

Ossification characteristic

        

 With bone marrow grade

Idiopathic

1

2

12

3

15/18

83.3

 

Secondary-All

2

2

2

1

3/7

42.8

NS

Secondary-Af

2

1

0

0

0/3

0

< 0.05

 Ossification MAX size grade

Idiopathic

0

1

11

6

17/18

94.4

 

Secondary-All

1

2

2

2

4/7

57.1

< 0.05

Secondary-Af

2

1

0

0

0/3

0

< 0.05

Fibrosis

        

 Subpleural fibrosis grade

Idiopathic

17

1

0

0

0/18

0

< 0.01

Secondary

 

2

3

2

5/7

71.4

 OP grade

Idiopathic

15

3

0

0

0/18

0

< 0.05

Secondary

2

2

0

3

3/7

42.8

 Cicatricial OP (CiOP-grade)

Idiopathic

1

6

9

2

11/18

61.1

NS

Secondary

0

2

3

2

5/7

71.4

  1. I-DiPO idiopathic diffuse pulmonary ossification; S-DiPO, secondary diffuse pulmonary ossification; NS, not significant; F test, Fisher’s exact test; Secondary-All, all S-DiPO cases; Secondary-Af, S-DiPO cases with atrial fibrillation [Af]; OP, organising pneumonia.
  2. Values indicate the number of cases.
  3. G0: grade 0, none; G1: mild; G2: moderate; G3: severe.
  4. To compare the pathological features between I-DiPO and S-DiPO, Fisher’s exact test was used to evaluate the dendriform type. All other pathological parameters were expressed as a ratio of higher grades (number of patients with G2 and G3/number patients with all grades). Only patients with S-DiPO and atrial fibrillation were further compared with those with I-DiPO in terms of ossification characteristics (type, maximum size, and bone marrow component).