Fig. 3
Identification of LUAD-associated modules and RBM genes intersections. (a) Both RBMS2 and RBMS3 were identified within the MEblue module, indicating their strong association with LUAD. (b) Overlap analysis of DEGs between the GSE116959 and TCGA datasets and the MEblue module genes revealed 651 co-DEGs, including RBMS3. (c) Functional enrichment analysis of MEblue DEGs using Gene Ontology (GO) revealed significant enrichment in the canonical Wnt signaling pathway and the regulation of the canonical Wnt signaling pathway, both of which play pivotal roles in cancer development. (d) Enrichment analysis of MEblue DEGs using the KEGG database indicated that these genes are significantly involved in several cancer-related signaling pathways, including Proteoglycans in cancer, MAPK signaling pathway, Renal cell carcinoma, and Transcriptional misregulation in cancer. e PPI network analysis illustrated the interactions and functional roles of DEGs within the MEblue module. RBMS3 was identified as a central gene within this network, underscoring its potential pivotal role in LUAD development.
