Fig. 1 | Scientific Reports

Fig. 1

From: Synergistic activity of tafasitamab and metronomic chemotherapy on diffuse large B-cell lymphoma through inhibition of the AKT/mTOR signaling pathway

Fig. 1

In vitro cytotoxic and pro-apoptotic activity. In vitro effect of metronomic etoposide (A), metronomic vinorelbine (VNR) (B) and tafasitamab (C) on viability of Toledo, OCI-LY3 and SU-DHL10 cell lines after 144 h of exposure. Symbols and bars, mean values ± S.E.M., respectively. Pro-apoptotic activity in Toledo (D), OCI-LY3 (E) and SU-DHL10 (F) cell lines treated with tafasitamab alone and in combination with metronomic vinorelbine (VNR) and metronomic etoposide (ETO) at the experimental IC50 for 48 h when compared to the IgG1 isotype control cells. Columns and bars, mean values ± S.E.M., respectively. *P < 0.05 vs. human IgG1 isotype controls.

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