Fig. 4

Change in serum creatinine levels. The figure presents a two-part plot depicting box plots and mean change in serum creatinine from the lowest value in the 7 days preceding each measurement. Panels (a–c) shows the absolute change in mg/dL for maximum KDIGO-UO staging 1–3, while panels (d–f) shows the relative change for the same maximum staging, which is unitless. The x-axis represents the time to AKI onset in hours, ranging from 24 h before the event to 48 h after, in 6-h intervals.