Fig. 1
From: Lethal toxicity of metformin on zebrafish during early embryonic development by multi-omics analysis
(A) Phenotype of zebrafish embryos at 24, 48, 72 hpf in the control and 800 mM treatment group. (B) Deformity rate curves of zebrafish exposed to different concentrations of metformin (0–96 hpf). Unpaired t-test was used to test for statistical significance *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001, the same as below. (C) Survival rate curves of zebrafish exposed to different metformin concentrations (0–96 hpf). (D) The 24 hpf LC50 value of metformin to zebrafish embryos. (E) Hatching rate of embryos on the third day. (F) Embryonic organizer and germ layer marker expression detected by WISH during gastrulation.
