Fig. 8
From: Cathepsin D inhibits AGEs-induced phenotypic transformation in vascular smooth muscle cells
Combined analysis of the metabolomic and transcriptomic profiles of AG-Es-induced VSMCs with CTSD overexpression. (A) Venn diagram of common KEGG enriched pathways for differentially expressed genes and differential metabolites among the N-A, N-B, and T-A groups. (B) Top 20 KEGG enriched pathways shared among the N-A, N-B, and T-A groups. (C) Relative expression levels of GLUT1, GCK, PFKL, and PKM2 in VSMCs detected by western blotting. All data are presented as mean ± SEM (n = 3). * represents p < 0.05, ** represents p < 0.01. Note: In the figure, GLUT1 stands for Glucose Transporter 1, GCK for Glucokinase, PFKL for Phosphofructokinase, and PKM2 for Pyruvate Kinase M2.
