Table 1 Comparing the performance between AutScore, AutScore.r and autocasc in detecting ASD candidate variants.

From: An integrative scoring approach for prioritization of rare autism spectrum disorder candidate variants from whole exome sequencing data

Scoring Approaches

Sensitivity

Specificity

PPV

Accuracy

(95% C.I.)

Yield (%) (Likely)

AutScore (≥ 12)

0.91

0.62

0.58

0.72 (0.65, 0.79)

9.81

AutScore.r (≥ 0.335)

0.81

0.87

0.79

0.85 (0.79, 0.90)

8.78

AutoCasC (> 6)

0.92

0.13

0.4

0.43 (0.36, 0.51)

9.98

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