Fig. 6
From: Dose-dependent dual effects of HDAC inhibitors on glial inflammatory response
(A) Scatter plots of log2 intensity values of DEGS. Total number of DEGs (red dots) identified for glial cells treated with SAHA 100 nM or SAHA 5 uM compared to LPS (10 ng/ml) condition. DEGs identified with the Limma algorithm with a threshold value of 0.01. On the y-axis are reported the means of the replicates of the treatment conditions and on the x-axis the mean across the replicates of the reference condition (LPS 10 ng/ml). (B) Pathway enrichment analysis. KEGG functional summary reporting the enrichment p-values less than 0.05 (log10 of p-value) for the different annotation terms LPS_SAHA100 - LPS and LPS_SAHA5—LPS. The color scheme is based on a simple scale (reported above) painting pathways (blu down – and red up- regulated) by automatic analysis using basic analysis.
