Fig. 1 | Scientific Reports

Fig. 1

From: Multiple subcortical and subcortico–cortico dynamic network reconfigurations characterize focal-to-bilateral tonic–clonic seizures

Fig. 1

Schematic overview of the approach. (a) BOLD signal was extracted from the Schaefer parcels corresponding to the Yeo 7-networks53 (visual [purple], somatomotor [blue], DAN [green], VAN [violet], limbic [yellow], control [orange] and DMN [red]); thalamus [red], striatum (globus pallidus [not visible], nucleus accumbens [purple], caudate [violet] and putamen [green]) and mesial temporal (hippocampus [yellow] and amygdala [pink]) systems from Melbourne atlas47 and 7 cerebellar subsystems (color coded based on its maximal functional correlation with a Schaefer cerebral network) using the Buckner atlas—at individual level48. (b) Time series were extracted from the Schaefer 200 parcels, Melbourne 54 parcels and 7 cerebellar parcels using RS fMRI data. (c) A sliding window strategy (length/step = 40/20 s, 23 windows in total) was used to generate inter-regional coherence matrices over time. (d) Dynamic community structure was detected by maximizing a multilayer modularity quality function78. (e) Community identities were sorted for each parcel over time (Module Allegiance50,55). (f) Dynamic properties were estimated50,51,78. DAN = dorsal attention network; VAN = ventral attention network; DMN = default mode network; RS fMRI = resting state functional MRI.

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