Table 3 Results of Healthy Participants versus LTLE group for two-way repeated-measures MANOVA for subsystem integration between the four subcortical/cortical subsystem combinations (thalamus, striatum, mesial-temporal and cerebellar subsystems with all cortical subsystems).

From: Multiple subcortical and subcortico–cortico dynamic network reconfigurations characterize focal-to-bilateral tonic–clonic seizures

Source	df or Hypothesis df/error df	F	Sig	Partial Eta Squared	Observed Power
Between anterior thalamus/cortical subsystems
WS Hemisphere	1	0.019	0.889	0.000	0.052
WS Hemisphere X Group	1	3.526	0.063	0.031	0.461
WS Subsystems X Group	4.562	1.102	0.357	0.010	0.374
^jWS Hemisphere X Subsystem	6.793	5.213	0.000	0.046	0.999
WS Hemisphere X Subsystem X Group	6.793	0.339	0.932	0.003	0.154
BTWS Group	1/109	0.340	0.561	0.003	0.089
Between posterior thalamus/cortical subsystems
WS Hemisphere	1	1.501	0.223	0.014	0.229
WS Hemisphere X Group	1	0.055	0.815	0.001	0.056
WS Subsystems X Group	6.051	0.747	0.613	0.007	0.300
^kWS Hemisphere X Subsystem	6.510	3.774	0.001	0.033	0.973
^lWS Hemisphere X Subsystem X Group	6.510	1.773	0.096	0.016	0.698
BTWS Group	1/109	0.686	0.409	0.006	0.130
Between Putamen/cortical subsystems
WS Hemisphere	1	0.129	0.720	0.129	0.065
WS Hemisphere X Group	1	2.609	0.109	0.023	0.360
^mWS Subsystems X Group	4.625	2.144	0.064	0.019	0.682
ⁿWS Hemisphere X Subsystem	6.398	7.149	0.000	0.062	1.000
WS Hemisphere X Subsystem X Group	6.398	0.230	0.972	0.002	0.114
BTWS Group	1/109	0.201	0.655	0.002	0.073
Between Caudate/cortical subsystems
WS Hemisphere	1	3.330	0.071	0.030	0.440
WS Hemisphere X Group	1	0.097	0.757	0.001	0.061
WS Subsystems X Group	4.261	0.801	0.532	0.007	0.266
^oWS Hemisphere X Subsystem	6.511	2.894	0.007	0.026	0.914
WS Hemisphere X Subsystem X Group	6.511	0.688	0.672	0.006	0.288
BTWS Group	1/109	0.046	0.831	0.000	0.055
Between Globus Pallidus/cortical subsystems
WS Hemisphere	1	2.295	0.133	0.021	0.324
WS Hemisphere X Group	1	0.928	0.338	0.008	0.159
WS Subsystems X Group	4.812	1.386	0.230	0.013	0.481
WS Hemisphere X Subsystem	7.194	0.891	0.515	0.008	0.396
WS Hemisphere X Subsystem X Group	7.194	0.945	0.473	0.009	0.419
BTWS Group	1/109	0.501	0.480	0.005	0.108
Between Nucleus Accumbens/cortical subsystems
WS Hemisphere	1	0.558	0.457	0.005	0.115
WS Hemisphere X Group	1	0.067	0.796	0.001	0.058
WS Subsystems X Group	5.064	0.897	0.484	0.008	0.325
WS Hemisphere X Subsystem	5.997	1.811	0.094	0.016	0.682
WS Hemisphere X Subsystem X Group	5.997	0.546	0.773	0.005	0.221
BTWS Group	1/109	0.136	0.713	0.001	0.136
Between Anterior hippocampus/cortical subsystems
WS Hemisphere	1	0.258	0.612	0.002	0.080
WS Hemisphere X Group	1	0.159	0.691	0.001	0.068
WS Subsystems X Group	5.400	0.994	0.424	0.009	0.373
^pWS Hemisphere X Subsystem	6.050	4.491	0.000	0.040	0.987
WS Hemisphere X Subsystem X Group	6.050	1.047	0.394	0.010	0.419
BTWS Group	1/109	0.023	0.879	0.000	0.053
Between posterior hippocampus/cortical subsystems
WS Hemisphere	1	0.580	0.448	0.005	0.117
WS Hemisphere X Group	1	0.527	0.469	0.005	0.111
WS Subsystems X Group	5.544	0.727	0.617	0.007	0.279
^qWS Hemisphere X Subsystem	6.333	5.359	0.00	0.047	0.997
^rWS Hemisphere X Subsystem X Group	6.333	2.640	0.014	0.024	0.876
BTWS Group	1/109	0.073	0.788	0.001	0.058
Between amygdala/cortical subsystems
WS Hemisphere	1	2.274	0.134	0.020	0.321
WS Hemisphere X Group	1	0.001	0.977	0.000	0.050
WS Subsystems X Group	4.964	0.384	0.859	0.004	0.150
^sWS Hemisphere X Subsystem	6.304	3.874	0.001	0.034	0.974
WS Hemisphere X Subsystem X Group	6.304	1.296	0.254	0.012	0.527
BTWS Group
Between Cereb1/cortical subsystems
WS Hemisphere	1	2.011	0.159	0.018	0.290
WS Hemisphere X Group	1	2.033	0.157	0.018	0.293
WS Subsystems X Group	5.160	0.574	0.725	0.005	0.215
^tWS Hemisphere X Subsystem	5.740	2.009	0.066	0.018	0.721
^uWS Hemisphere X Subsystem X Group	5.740	1.528	0.170	0.014	0.580
BTWS Group	1/109	0.134	0.715	0.001	0.065
Between Cereb2/cortical subsystems
WS Hemisphere	1	0.110	0.740	0.001	0.063
^vWS Hemisphere X Group	1	6.068	0.015	0.053	0.685
WS Subsystems X Group	5.407	0.799	0.560	0.007	0.301
^wWS Hemisphere X Subsystem	6.106	3.009	0.006	0.027	0.912
WS Hemisphere X Subsystem X Group	6.106	0.806	0.567	0.007	0.325
BTWS Group	1/109	0.905	0.343	0.008	0.156
Between Cereb3/cortical subsystems
WS Hemisphere	1	0.055	0.814	0.001	0.056
WS Hemisphere X Group	1	0.459	0.500	0.004	0.103
WS Subsystems X Group	5.728	1.561	0.160	0.014	0.590
^xWS Hemisphere X Subsystem	6.467	2.185	0.038	0.020	0.801
WS Hemisphere X Subsystem X Group	6.467	0.743	0.625	0.007	0.310
BTWS Group	1/109	0.434	0.512	0.004	0.100
Between Cereb4/cortical subsystems
WS Hemisphere	1	0.791	0.376	0.007	0.143
WS Hemisphere X Group	1	0.013	0.910	0.000	0.051
WS Subsystems X Group	5.309	1.740	0.119	0.016	0.621
^yWS Hemisphere X Subsystem	6.169	4.574	0.000	0.040	0.989
WS Hemisphere X Subsystem X Group	6.169	0.383	0.895	0.003	0.164
BTWS Group	1/109	0.038	0.847	0.000	0.054
Between Cereb5/cortical subsystems
WS Hemisphere	1	0.014	0.906	0.000	0.052
WS Hemisphere X Group	1	0.047	0.829	0.000	0.055
WS Subsystems X Group	5.707	0.486	0.810	0.004	0.194
WS Hemisphere X Subsystem	6.788	1.585	0.139	0.014	0.654
WS Hemisphere X Subsystem X Group	6.788	1.732	0.101	0.016	0.701
BTWS Group	1/109	0.433	0.512	0.004	0.100
Between Cereb6/cortical subsystems
WS Hemisphere	1	0.880	0.350	0.008	0.153
^zWS Hemisphere X Group	1	4.831	0.030	0.042	0.587
WS Subsystems X Group	5.179	1.617	0.151	0.015	0.576
^aaWS Hemisphere X Subsystem	6.395	2.719	0.011	0.024	0.889
WS Hemisphere X Subsystem X Group	6.395	0.468	0.843	0.004	0.198
BTWS Group	1/109	0.217	0.643	0.002	0.075
Between Cereb7/cortical subsystems
WS Hemisphere	1	1.474	0.227	0.013	0.225
WS Hemisphere X Group	1	1.907	0.170	0.017	0.278
WS Subsystems X Group	4.915	1.257	0.281	0.011	0.444
^abWS Hemisphere X Subsystem	7.208	3.540	0.001	0.031	0.975
WS Hemisphere X Subsystem X Group	7.208	0.250	0.974	0.002	0.126
BTWS Group	1/109	0.035	0.852	0.000	0.054

The univariate test results showing main effects and interactions of condition, experimental group, and subsystems for integration. Pairwise comparisons were also tested for the results showing a significant univariate effect to determine the nature of the differences between those variables (See suppl. section). WS—Within-subject effect, BTWS—Between-subject effect.
*Multivariate effect is significant at p < .05 or less.
Significant differences are highlighted in bold. Trends are italicized.

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Table 3 Results of Healthy Participants versus LTLE group for two-way repeated-measures MANOVA for subsystem integration between the four subcortical/cortical subsystem combinations (thalamus, striatum, mesial-temporal and cerebellar subsystems with all cortical subsystems).

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